Fragment-ion and amino-acid probability models

adjacent · Transformer (encoder-only)

Fragment-ion and amino-acid probability models: adjacent · Transformer (encoder-only). Two local probability-prediction tasks for tandem mass spectra, aimed at telling sequence-informative fragment evidence from noise and from merely unobserved…

Two local probability-prediction tasks for tandem mass spectra, aimed at telling sequence-informative fragment evidence from noise and from merely unobserved fragments. Fragment-Ion Probability scores whether a peak-supported mass position is a sequence-informative fragment ion; Amino Acid Probability scores whether two mass-consistent positions are adjacent fragments joined by a candidate residue. Encoder-only Transformers outperform CNN baselines on both, and feeding the probabilities to a separate sequencer raises amino-acid recall, amino-acid precision and peptide recall.

Kind adjacent
Family Transformer (encoder-only)
Deep learning yes
Acquisition DDA

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Authors (1)

Shichao Wang

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