NovelNSeq
adjacent
NovelNSeq: adjacent. Dedicated algorithm for novel N-terminal proteoforms arising from alternative splicing, parsing signature N-terminal extension peptides. Positioned as an alternative to…
Dedicated algorithm for novel N-terminal proteoforms arising from alternative splicing, parsing signature N-terminal extension peptides. Positioned as an alternative to both proteogenomics, which cannot see proteins absent from the transcriptome, and de novo sequencing, which the authors argue lacks the accuracy and traceability required here.
| Kind | adjacent |
| Deep learning | no |
| Acquisition | DDA |
Papers
- Precise Discovery of Novel N-Terminal Proteoforms beyond the Limitations of Proteogenomics and De Novo Sequencing (2025, Analytical Chemistry, peer-reviewed)