PepPr
algorithm · Transformer (AR)
PepPr: algorithm · Transformer (AR). A peptide language model fitted to a reference proteome, fused through a small learned head with the next-residue logits of an autoregressive sequencer (Casanovo or…
A peptide language model fitted to a reference proteome, fused through a small learned head with the next-residue logits of an autoregressive sequencer (Casanovo or ContraNovo) before beam search, so reference context fills gaps in incomplete spectra without excluding variants.
| Kind | algorithm |
| Deep learning | yes |
| Acquisition | DDA |
| Family | Transformer (AR) |
Code
Live stars, open issues and last-push figures are on the Code activity chart.
Checkpoints
| Version | Trained on | Host | Licence | Size | Checked |
|---|---|---|---|---|---|
| bioRxiv v1 | priors: reference proteomes and immunoglobulin germline alleles (IMGT); fusion heads: a subset of Casanovo’s MassIVE-KB v1 training split | Zenodo archival | CC-BY-4.0 | 11.3 GB | live 2026-10-29 |
Data
What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.
Trained on
- Fit for Purpose Approach to Evaluate Detection of Amino Acid Substitutions in Shotgun Proteomics (as deposited)
- MassIVE-KB (v1 30M-PSM split (Casanovo))
Evaluated on
- Monoclonal antibody de novo assembly (as deposited)
- Nine-species benchmark (revised (build not stated))
- PXD060500 (as deposited)
- ProteomeTools (single amino-acid variants (SAAV))
- Proteomic diversity in bacteria: Insights and implications for bacterial identification (as deposited)
- The Proteome Landscape of the Kingdoms of Life (as deposited)
Deposited
- Benchmark data and evaluation results for PepPr (as deposited)
Paper describing it
- PepPr: De Novo peptide sequencing with peptide priors (2026, bioRxiv, preprint)