pUniFind
algorithm · Transformer (AR)
pUniFind: algorithm · Transformer (AR). Multimodal pre-trained transformer for mass spectra that unifies peptide-spectrum scoring and zero-shot de novo sequencing in a single model. Trained on >100M…
Multimodal pre-trained transformer for mass spectra that unifies peptide-spectrum scoring and zero-shot de novo sequencing in a single model. Trained on >100M open-search-derived spectra; reports +60% PSMs over prior de novo methods with 1,300+ modifications supported, and a DL-based QC step that recovers 38.5% additional peptides.
| Kind | algorithm |
| Family | Transformer (AR) |
| Deep learning | yes |
| Acquisition | DDA |
Papers
- A large-scale unified deep learning model for peptide mass spectrum interpretation trained on multimodal data (2026, Nature Machine Intelligence, peer-reviewed)
- pUniFind: a unified large pre-trained deep learning model pushing the limit of mass spectra interpretation (2025, arXiv, preprint)