RNovA
algorithm · Transformer (AR)
RNovA: algorithm · Transformer (AR). Zero-shot open PTM discovery
Zero-shot open PTM discovery
| Kind | algorithm |
| Deep learning | yes |
| Acquisition | DDA |
| Family | Transformer (AR) |
Code
Live stars, open issues and last-push figures are on the Code activity chart.
Data
What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.
Trained on
- MassIVE-KB (version not stated) · 2025 preprint, 2026 peer-reviewed
Evaluated on
- A quantitative and site-specific atlas of the PADI4-induced citrullinome reveals widespread existence of citrullination (as deposited) · 2025 preprint, 2026 peer-reviewed
- CHPP chr 1,8,20 proteome dataset using the HCC cell lines of Hep3B and MHCC97H, instrument is Q Exactive, part 2 of 3 (as deposited) · 2026 peer-reviewed
- CHPP chr 1,8,20 proteome dataset using the HCC cell lines of MHCC97H and HCCLM3, instrument is Q Exactive, part 1 of 3 (as deposited) · 2026 peer-reviewed
- GraphNovo dataset and checkpoint (version not stated) · 2026 peer-reviewed
- GraphNovo dataset and checkpoint (as deposited) · 2025 preprint
- ProteomeTools (21-PTM subset) · 2025 preprint, 2026 peer-reviewed
- RNovA Test Datasets (as deposited) · 2025 preprint
- Zero-Shot De Novo Peptide Sequencing with Open Post-Translational Modification Discovery (as deposited) · 2026 peer-reviewed
Deposited
- RNovA Test Datasets (as deposited) · 2025 preprint
- Zero-Shot De Novo Peptide Sequencing with Open Post-Translational Modification Discovery (as deposited) · 2026 peer-reviewed
Benchmarks
- denovo_benchmarks: median peptide-level average precision 0.825 over 86 datasets, median rank 4 of 15 (version 1.0.0).
Both are mass-based matches on the tool’s most recent run. What these numbers mean.
Papers describing it (2)
- Zero-Shot De Novo Peptide Sequencing with Open Post-Translational Modification Discovery (2025, Research Square, preprint)
- Zero-shot de novo peptide sequencing with open posttranslational modification discovery (2026, Nature Biotechnology, peer-reviewed)