RNovA

algorithm · Transformer (AR)

RNovA: algorithm · Transformer (AR). Zero-shot open PTM discovery

Zero-shot open PTM discovery

Kind	algorithm
Deep learning	yes
Acquisition	DDA
Family	Transformer (AR)

Code

• https://github.com/zqq66/RNovA
• https://github.com/AmadeusloveIris/RNovA_SeqFiller_Inference

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Papers describing it (2)

• Zero-Shot De Novo Peptide Sequencing with Open Post-Translational Modification Discovery (2025, Research Square, preprint)
• Zero-shot de novo peptide sequencing with open posttranslational modification discovery (2026, Nature Biotechnology, peer-reviewed)

Authors (11)

Zeping Mao, Chao Peng, Yuling Chen, Ping Wu, Qianqiu Zhang, Lei Xin, Haiteng Deng, Ming Li, Yonghan Yu, Ruixue Zhang, Baozhen Shan

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