Lock mass ions for use with derivatized peptides for de novo sequencing using tandem mass spectrometry
US20060014293A1 · Agilent Technologies · priority 2004
| Patent | US20060014293A1 ↗ |
| Status | Abandoned |
| Priority date | 2004-07-16 |
| Filed | 2004-09-10 |
| Published | 2006-01-19 |
| Assignee | Agilent Technologies (printed Agilent Technologies Inc) |
| Also published as | EP1617224A1 |
Abstract
Multiple derivatization by chemical reactions of analytes for mass spectrometry is disclosed. The derivatizations enhance the use of MS techniques for analyzing protein samples, particularly when the sequence of a polypeptide is determined by tandem MS/MS. Accurate mass analysis techniques are described for use in sequencing polypeptides, together with the use of sequencing data in protein analysis. An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is also provided. Lock mass ions mix with the derivatized polypeptide analyte ions prior to mass analysis.
Why it is here
Agilent: lock-mass ions for accurate-mass analysis of doubly derivatised peptides, to determine their sequence. Abandoned application.
Inventors (4)
Timothy Joyce, Barry Boyes, Gordon Nicol, Hongbin Liu
An inventor links to an author page only where the same person is evident, never on a name alone.
Cited by (2 patent families, 2 organisations)
- Mds Analytical Technologies, A Business Unit of Mds Inc., Doing Business Through Its Sciex Division company: CA2696167A1
- Rudjer Boskovic Institute academic: EP2710380B1
Every family, of any applicant, that cites this one, as Google Patents lists them; an assignee is given its English name.