AL amyloid light-chain proteoform sequencing
downstream-application
AL amyloid light-chain proteoform sequencing: downstream-application. Pipeline for systemic AL amyloidosis that combines intact-mass Q-TOF measurement before and after deglycosylation with multi-protease digestion and de novo peptide…
Pipeline for systemic AL amyloidosis that combines intact-mass Q-TOF measurement before and after deglycosylation with multi-protease digestion and de novo peptide sequencing, linking urinary N-glycosylated light-chain proteoforms to in situ renal amyloid deposits.
| Kind | downstream-application |
| Deep learning | no |
| Acquisition | DDA |
| Application area | Antibodyomics |
Paper describing it
- Mass Spectrometry-Based De Novo Sequencing of N-Glycosylated Light Chains: Linking Urinary Proteoforms to In Situ Renal Amyloid Deposits (2026, Molecular & Cellular Proteomics, peer-reviewed)