Anti-Ro52 autoantibody sequencing in Sjogren’s syndrome
downstream-application
Anti-Ro52 autoantibody sequencing in Sjogren’s syndrome: downstream-application. De novo sequencing of purified anti-Ro52 autoantibodies, matched to IMGT, showed that isolated anti-Ro52 patients have less isotype switching, narrower…
De novo sequencing of purified anti-Ro52 autoantibodies, matched to IMGT, showed that isolated anti-Ro52 patients have less isotype switching, narrower variable-region usage and less somatic hypermutation.
| Kind | downstream-application |
| Deep learning | no |
| Acquisition | DDA |
| Application area | Antibodyomics |
Paper describing it
- Isolated anti-Ro52 identifies a severe subset of Sjögren’s syndrome patients (2023, Frontiers in Immunology, peer-reviewed)