Camelid VHH top-down sequencing

downstream-application

Camelid VHH top-down sequencing: downstream-application. Determines the primary structure of a 13.6 kDa camelid single heavy chain antibody by MALDI-TOF/TOF top-down analysis, recovering most of the sequence from the intact…

Determines the primary structure of a 13.6 kDa camelid single heavy chain antibody by MALDI-TOF/TOF top-down analysis, recovering most of the sequence from the intact protein rather than from peptides.

Kind	downstream-application
Deep learning	no
Acquisition	DDA
Application area	Antibodyomics

Papers describing it (2)

• Top-Down de Novo Protein Sequencing of a 13.6 kDa Camelid Single Heavy Chain Antibody by Matrix-Assisted Laser Desorption Ionization-Time-of-Flight/Time-of-Flight Mass Spectrometry (2010, Analytical Chemistry, peer-reviewed)
• Mass Spectrometric Protein Sequencing de Novo: The Full Determination of a 13.7 kDa Camelid Nanobody Sequence by MALDI Top-Down-Sequencing (2010, PubMed Central, abstract)

Authors (8)

Anja Resemann, Dirk Wunderlich, Ulrich Rothbauer, Bettina Warscheid, Heinrich Leonhardt, Jens Fuchser, Katja Kuhlmann, Detlev Suckau

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