Casanovo Foundation

algorithm · Transformer (AR)

Casanovo Foundation: algorithm · Transformer (AR). Foundation model for tandem-MS proteomics: pre-trained the Casanovo spectrum encoder on 30M labelled spectra from MassIVE-KB, then reused the encoder off-the-shelf for…

Foundation model for tandem-MS proteomics: pre-trained the Casanovo spectrum encoder on 30M labelled spectra from MassIVE-KB, then reused the encoder off-the-shelf for downstream tasks (de novo sequencing, spectrum quality, chimericity, phosphorylation, glycosylation prediction). Successor in spirit to Casanovo v1/v2/v5. The peer-reviewed version (MCP 2026) names the framework CasanovoTL.

Kind algorithm
Deep learning yes
Acquisition DDA
Also known as CasanovoTL
Family Transformer (AR)

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Data

What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.

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Also used, purpose not recorded

Papers describing it (2)

Authors (8)

Justin Sanders, Melih Yilmaz, Jacob H. Russell, Wout Bittremieux, William E. Fondrie, Nicholas M. Riley, Sewoong Oh, William Stafford Noble

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