CHO C-terminal Fc-extension discovery
downstream-application
CHO C-terminal Fc-extension discovery: downstream-application. De novo sequencing of a 1177 Da Fc impurity revealed an unexpected splicing-derived extension, fixed by changing the glycine codon.
De novo sequencing of a 1177 Da Fc impurity revealed an unexpected splicing-derived extension, fixed by changing the glycine codon.
| Kind | downstream-application |
| Acquisition | DDA |
| Application area | Antibodyomics |
Paper describing it
- Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells (2018, mAbs, peer-reviewed)