CRC cryptic peptide T-cell stimulation
downstream-application
CRC cryptic peptide T-cell stimulation: downstream-application. Characterises the HLA ligandome of two hypermutated colorectal cancers, finding 97 cryptic tumour-specific candidates with the de novo-based Peptide-PRISM, and shows…
Characterises the HLA ligandome of two hypermutated colorectal cancers, finding 97 cryptic tumour-specific candidates with the de novo-based Peptide-PRISM, and shows patients’ T cells stimulated with them recognise autologous tumour cells.
| Kind | downstream-application |
| Deep learning | no |
| Acquisition | DDA |
| Application area | Immunopeptidomics / neoantigen |
Paper describing it
- T cells of colorectal cancer patients’ stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells (2022, Journal for ImmunoTherapy of Cancer, peer-reviewed)