cryoEM + MS antibody sequencing workflow

adjacent

cryoEM + MS antibody sequencing workflow: adjacent. Workflow combining cryoEM-derived sequences (via ModelAngelo) with LC-MS/MS-based assembly (via Stitch) for simultaneous polyclonal antibody sequencing and epitope…

Workflow combining cryoEM-derived sequences (via ModelAngelo) with LC-MS/MS-based assembly (via Stitch) for simultaneous polyclonal antibody sequencing and epitope mapping. Reports 80–90% accuracy on antibody variable domains and improves MS-based assembly against polyclonal backgrounds.

Kind	adjacent
Acquisition	DDA

Papers

• Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry (2025, eLife, peer-reviewed)

Authors (4)

Douwe Schulte, Marta Šiborová, Lukas Käll, Joost Snijder

Seen in the charts

• Models and the authors behind them

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