Cumulative MS score (cMS)

algorithm · Grouped spectra

Cumulative MS score (cMS): algorithm · Grouped spectra. Scoring framework that accumulates evidence for a residue across repeated injections rather than scoring one spectrum at a time, to make de novo annotation robust enough…

Scoring framework that accumulates evidence for a residue across repeated injections rather than scoring one spectrum at a time, to make de novo annotation robust enough to read VH/VL and CDR sequences out of a POLYCLONAL antibody mixture.

Kind	algorithm
Family	Grouped spectra
Deep learning	no
Acquisition	DDA

Code

• https://github.com/cguetot/cms

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Papers

• Cumulating MS Signal enables polyclonal antibody analysis (2025, bioRxiv, preprint)

Authors (8)

Carlos Gueto-Tettay, Joel Ströbaek, Di Tang, Alejandro Gomez Toledo, Yasaman Karami, Hammed Khakzad, Johan Malmström, Lars Malmström

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