DIANovo

algorithm · Transformer (AR)

DIANovo: algorithm · Transformer (AR). Transformer-based de novo sequencer for DIA: disentangles coeluted/multiplexed precursor spectra. Presented in Zheng Ma’s arXiv preprint (2024) and his PhD thesis (2025).

Transformer-based de novo sequencer for DIA: disentangles coeluted/multiplexed precursor spectra. Presented in Zheng Ma’s arXiv preprint (2024) and his PhD thesis (2025).

Kind	algorithm
Family	Transformer (AR)
Deep learning	yes
Acquisition	DIA

Code

• https://github.com/hearthewind/dianovo

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Papers

• Advancing Proteomic Analyses with Graph-Based Deep Learning: Protein Inference and DIA De Novo Peptide Sequencing (2025, thesis)
• Disentangling the Complex Multiplexed DIA Spectra in De Novo Peptide Sequencing (2024, arXiv, preprint)

Authors (8)

Zheng Ma, Zeping Mao, Ruixue Zhang, Jiazhen Chen, Lei Xin, Baozhen Shan, Ali Ghodsi, Ming Li

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