Differential scanning de novo sequencing
algorithm
Differential scanning de novo sequencing: algorithm. Resolves the ion-type ambiguity that makes a tandem mass spectrum hard to read by acquiring the same peptide under differing conditions and comparing the scans, so a…
Resolves the ion-type ambiguity that makes a tandem mass spectrum hard to read by acquiring the same peptide under differing conditions and comparing the scans, so a fragment’s series can be assigned rather than inferred. Aimed at organisms whose genomes are not sequenced, where a database is not an option.
| Kind | algorithm |
| Deep learning | no |
| Acquisition | DDA |
Papers describing it (2)
- Automatedde novo sequencing of proteins using the differential scanning technique (2001, PROTEOMICS, peer-reviewed)
- De novo Sequencing of Proteins With Mass Spectrometry Using the Differential Scanning Technique (2011, Proteome and Protein Analysis, peer-reviewed)