DiffNovo-DIA

algorithm · Diffusion

DiffNovo-DIA: algorithm · Diffusion. Transformer-diffusion model for DIA de novo peptide sequencing: DIA-side companion to DiffNovo, extending Transformer-DIA (DiaTrans) with a diffusion model. From Shiva…

Transformer-diffusion model for DIA de novo peptide sequencing: DIA-side companion to DiffNovo, extending Transformer-DIA (DiaTrans) with a diffusion model. From Shiva Ebrahimi’s PhD thesis (UNT, 2025). The code is in her own GitHub repository (Apache-2.0) and on PyPI (diffnovo-dia v0.1.2); the lab repository the package points to is still empty, and no standalone paper has been published.

Kind	algorithm
Deep learning	yes
Acquisition	DIA
Also known as	DiffNovo_DIA
Family	Diffusion

Code

• https://github.com/sadatebrahimi/DiffNovo-DIA
• https://pypi.org/project/diffnovo-dia/

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Paper describing it

• De Novo Peptide Sequencing for Data-independent Acquisition (DIA) Using Deep Learning (2025, thesis)

Authors (1)

Shiva Ebrahimi

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