Generative AI protein scaffold filling

post-processor · Sequence assembly

Generative AI protein scaffold filling: post-processor · Sequence assembly. Fills gaps in de novo protein scaffolds with denoising autoencoder, transformer and GPT-2 models, reaching complete accuracy on an antibody scaffold.

Fills gaps in de novo protein scaffolds with denoising autoencoder, transformer and GPT-2 models, reaching complete accuracy on an antibody scaffold.

Kind	post-processor
Deep learning	yes
Acquisition	DDA
Family	Sequence assembly

Paper describing it

• Generative AI Models for the Protein Scaffold Filling Problem (2025, Journal of Computational Biology, peer-reviewed)

Authors (6)

Letu Qingge, Kushal Badal, Richard Annan, Jordan Sturtz, Xiaowen Liu, Binhai Zhu (Montana State University)

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