IFN-alpha beta-cell HLA-I immunopeptidome
downstream-application
IFN-alpha beta-cell HLA-I immunopeptidome: downstream-application. A de novo sequencing-based immunopeptidomics pipeline showed that interferon-alpha expands the beta-cell HLA-I repertoire toward HLA-B and toward non-canonical peptides…
A de novo sequencing-based immunopeptidomics pipeline showed that interferon-alpha expands the beta-cell HLA-I repertoire toward HLA-B and toward non-canonical peptides from alternative and cis-splicing.
| Kind | downstream-application |
| Deep learning | no |
| Acquisition | DDA |
| Application area | Immunopeptidomics / neoantigen |
Data
What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.
Deposited
- HLA-peptidome of human beta cells exposed to interferon-alpha (as deposited)
- HLA-peptidome of human primary islets (as deposited)
Paper describing it
- Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells (2025, Nature Communications, peer-reviewed)