IFN-alpha beta-cell HLA-I immunopeptidome
downstream-application
IFN-alpha beta-cell HLA-I immunopeptidome: downstream-application. A de novo sequencing-based immunopeptidomics pipeline showed that interferon-alpha expands the beta-cell HLA-I repertoire toward HLA-B and toward non-canonical peptides…
A de novo sequencing-based immunopeptidomics pipeline showed that interferon-alpha expands the beta-cell HLA-I repertoire toward HLA-B and toward non-canonical peptides from alternative and cis-splicing.
| Kind | downstream-application |
| Deep learning | no |
| Acquisition | DDA |
| Application area | Immunopeptidomics / neoantigen |
Paper describing it
- Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells (2025, Nature Communications, peer-reviewed)