InstaNexus
post-processor · Sequence assembly
InstaNexus: post-processor · Sequence assembly. End-to-end workflow for reference-free sequencing of full-length protein therapeutics. Multi-protease digestion yields overlapping peptides, InstaNovo sequences them de…
End-to-end workflow for reference-free sequencing of full-length protein therapeutics. Multi-protease digestion yields overlapping peptides, InstaNovo sequences them de novo and Winnow rescores, then greedy overlap or de Bruijn graph assembly (default k=7, min overlap 3) reconstructs contigs ranked by a composite score over coverage, N50, scaffold count and identity. Validated on nanobodies, monoclonal antibodies and de novo mini-binders.
| Kind | post-processor |
| Deep learning | no |
| Acquisition | DDA |
| Family | Sequence assembly |
Code
Live stars, open issues and last-push figures are on the Code activity chart.
Data
What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.
Deposited
Also used, purpose not recorded
- ProteomeTools (Parts I-III) · 2025 preprint, 2026 peer-reviewed
Papers describing it (2)
- Generalizable direct protein sequencing with InstaNexus (2025, bioRxiv, preprint)
- Generalizable Direct Protein Sequencing With InstaNexus (2026, Molecular & Cellular Proteomics, peer-reviewed)