Log-transformed mass domain de novo sequencing
algorithm · Fragment ion analysis
Log-transformed mass domain de novo sequencing: algorithm · Fragment ion analysis. Bypasses averagine-based deconvolution by working directly in natural log-transformed m/z space, where charge-state spacing is mass-invariant and therefore supplies…
Bypasses averagine-based deconvolution by working directly in natural log-transformed m/z space, where charge-state spacing is mass-invariant and therefore supplies an intrinsic internal-calibration reference on both FT-ICR and Orbitrap. Isotopologue pairing in that domain then supports de novo sequencing of intact proteins.
| Kind | algorithm |
| Family | Fragment ion analysis |
| Deep learning | no |
| Acquisition | DDA |
Papers
- Mass-Invariant Natural Log-Transformed Mass Spectra Enable Internal Calibration and De Novo Sequencing of Intact Proteins (2026, Analytical Chemistry, peer-reviewed)