NovoCRF
algorithm · Graph / DP
NovoCRF: algorithm · Graph / DP. A conditional random field whose states are prefix masses, so every path is a peptide within 0.06 Da of the precursor; a 310k-parameter scorer of physics-derived…
A conditional random field whose states are prefix masses, so every path is a peptide within 0.06 Da of the precursor; a 310k-parameter scorer of physics-derived ion-match features is trained with exact global normalization over all mass-feasible peptides, decoded by exact k-best search and reranked by two BiGRUs.
| Kind | algorithm |
| Deep learning | yes |
| Acquisition | DDA |
| Family | Graph / DP |
Code
Not on the Code activity chart: the GitHub API has returned no figures for this repository, either because it was added after the last daily refresh or because it is private, renamed or deleted.
Data
What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.
Trained on
- CompOmics PRIDE (as published)
- MassIVE-KB (version not stated)
- ProteomeTools (version not stated)
Evaluated on
- Carbamazepine Activates Private Self and Viral Reactive TCRs Through a Drug-Permissive HLA-B Cleft (as deposited)
- Comprehensive proteogenomic analysis identifies immune targets in microsatellite stable and unstable colorectal cancers (as deposited)
- Functional diversification of the cephalopod proteome by RNA-editing (as deposited)
- Global proteomics of Peroxiredoxin 6 knockdown A549 cells subjected to ionizing radiation (as deposited)
- HLA class I-naturally presented synovial tissue peptides are recognized by CD8+ T lymphocytes from rheumatoid arthritis patients (as deposited)
- Peptidomics Mapping of Proteolysis Highlights Triple Activation of Sprouted Seeds by Germination, Homogenisation and Species Mixture. (as deposited)
- Protein-related hydrophobicity differences among strains belonging to Candidozyma auris (Candida auris) clades. (as deposited)
- Proteomic analysis of Xenopus tropicalis skin, toes, and claws using the GludC protease (as deposited)
- Proteomic data: The Japanese Archipelago sheltered cave lions, not tigers, during the Late Pleistocene (as deposited)
Paper describing it
- NovoCRF: Globally Normalized De Novo Peptide Sequencing on a Prefix-Mass Lattice (2026, arXiv, preprint)