Orthrus

downstream-application · Hybrid de novo + database search

Orthrus: downstream-application · Hybrid de novo + database search. Open-source metaproteomics pipeline combining Casanovo transformer-based de novo sequencing with Sage database search and Mokapot rescoring.

Open-source metaproteomics pipeline combining Casanovo transformer-based de novo sequencing with Sage database search and Mokapot rescoring.

Kind	downstream-application
Deep learning	yes
Acquisition	DDA
Family	Hybrid de novo + database search
Application area	Metaproteomics

Code

• https://github.com/yc386/orthrus_metaproteomics

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Data

What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.

Also used, purpose not recorded

• Paleofeces Analysis from Iron Age Hallstatt Salt Miners (as deposited)
• Profiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling de (as deposited)

Paper describing it

• Orthrus: an AI-powered, cloud-ready, and open-source hybrid approach for metaproteomics (2024, bioRxiv, preprint)

Authors (2)

Yun Chiang, Matthew James Collins

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