PolySeq.AI
downstream-application
PolySeq.AI: downstream-application. An automated workflow that integrates de novo bottom-up, middle-down and intact mass spectrometry to sequence polyclonal antibody mixtures without germline databases or…
An automated workflow that integrates de novo bottom-up, middle-down and intact mass spectrometry to sequence polyclonal antibody mixtures without germline databases or B-cell sequencing, validated by expressing recombinant antibodies.
| Kind | downstream-application |
| Deep learning | yes |
| Acquisition | DDA |
| Application area | Antibodyomics |
Paper describing it
- Sequencing of Polyclonal Antibodies by Integrating Intact Mass, Middle–Down, and De Novo Bottom–Up Mass Spectrometry (2025, Molecular & Cellular Proteomics, peer-reviewed)