PolySeq.AI

downstream-application

PolySeq.AI: downstream-application. An automated workflow that integrates de novo bottom-up, middle-down and intact mass spectrometry to sequence polyclonal antibody mixtures without germline databases or…

An automated workflow that integrates de novo bottom-up, middle-down and intact mass spectrometry to sequence polyclonal antibody mixtures without germline databases or B-cell sequencing, validated by expressing recombinant antibodies.

Kind	downstream-application
Deep learning	yes
Acquisition	DDA
Application area	Antibodyomics

Data

What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.

Deposited

• De Novo Sequencing of Polyclonal Antibodies by Integrating Intact Mass, Top-Down and Bottom-Up Mass Spectrometry (as deposited)

Paper describing it

• Sequencing of Polyclonal Antibodies by Integrating Intact Mass, Middle–Down, and De Novo Bottom–Up Mass Spectrometry (2025, Molecular & Cellular Proteomics, peer-reviewed)

Authors (15)

Lei Xin, Wenting Li, Shuyang Zhang, Ngoc Hieu Tran, Zheng Chen, Jun Ma, Chao Peng, Ailee Aihemaiti, Kyle Hoffman, Xiyue Zhang, Weiping Sun, Linting Li, Zihao Wang, Ming Li, Baozhen Shan

Seen in the charts

• Application areas
• Models and the authors behind them

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