Retention-time-aware de novo sequencing
algorithm · Graph / DP
Retention-time-aware de novo sequencing: algorithm · Graph / DP. Extends the symmetric difference scoring model with the chromatographic retention time, asking for a sequence consistent with both the fragment spectrum and the observed…
Extends the symmetric difference scoring model with the chromatographic retention time, asking for a sequence consistent with both the fragment spectrum and the observed elution time. Develops an algorithm for each of three retention-time prediction models.
| Kind | algorithm |
| Family | Graph / DP |
| Deep learning | no |
| Acquisition | DDA |
Papers
- Improved de novo peptide sequencing using LC retention time information (2018, Algorithms for Molecular Biology, peer-reviewed)