Retention-time-aware de novo sequencing

algorithm · Graph / DP

Retention-time-aware de novo sequencing: algorithm · Graph / DP. Extends the symmetric difference scoring model with the chromatographic retention time, asking for a sequence consistent with both the fragment spectrum and the observed…

Extends the symmetric difference scoring model with the chromatographic retention time, asking for a sequence consistent with both the fragment spectrum and the observed elution time. Develops an algorithm for each of three retention-time prediction models.

Kind	algorithm
Deep learning	no
Acquisition	DDA
Family	Graph / DP

Code

• https://github.com/tschager/denovort

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Paper describing it

• Improved de novo peptide sequencing using LC retention time information (2018, Algorithms for Molecular Biology, peer-reviewed)

Authors (4)

Yves Frank, Tomas Hruz, Thomas Tschager, Valentin Venzin

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