SpotLight proteomics

downstream-application

SpotLight proteomics: downstream-application. Combines de novo MS/MS sequencing of enriched antibodies and co-extracted proteins with label-free quantification of the new peptides, uncovering a hidden blood proteome…

Combines de novo MS/MS sequencing of enriched antibodies and co-extracted proteins with label-free quantification of the new peptides, uncovering a hidden blood proteome useful for patient stratification.

Kind	downstream-application
Deep learning	no
Acquisition	DDA
Application area	Antibodyomics

Papers describing it (2)

• SpotLight Proteomics: uncovering the hidden blood proteome improves diagnostic power of proteomics (2017, Scientific Reports, peer-reviewed)
• SpotLight Proteomics—A IgG-Enrichment Phenotype Profiling Approach with Clinical Implications (2019, International Journal of Molecular Sciences, peer-reviewed)

Authors (9)

Susanna L. Lundström, Bo Zhang, Dorothea Rutishauser, Dag Aarsland, Roman A. Zubarev, Tina Heyder, Emil Wiklundh, Anders Eklund, Johan Grunewald

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