Supernovo
algorithm · Template-guided assembly
Supernovo: algorithm · Template-guided assembly. Automated antibody de novo sequencing: finds the closest-matching germline V-J-C sequences by database search, then converges on the true heavy and light chains by…
Automated antibody de novo sequencing: finds the closest-matching germline V-J-C sequences by database search, then converges on the true heavy and light chains by iterative wildcard substitution against the MS/MS spectra. Commercial, shipped in Protein Metrics’ Byos platform.
| Kind | algorithm |
| Deep learning | no |
| Acquisition | DDA |
| Family | Template-guided assembly |
Paper describing it
- Automated Antibody De Novo Sequencing and Its Utility in Biopharmaceutical Discovery (2017, Journal of the American Society for Mass Spectrometry, peer-reviewed)
Paper using it
An application or evaluation that ran this method. It is not counted among its authors below.
- Template-Assisted De Novo Sequencing of SARS-CoV-2 and Influenza Monoclonal Antibodies by Mass Spectrometry (2022, Journal of Proteome Research, peer-reviewed)