Tetrazine-cyclized peptide UV ring-opening
algorithm · Chemical derivatization assisted
Tetrazine-cyclized peptide UV ring-opening: algorithm · Chemical derivatization assisted. Designs cyclic peptides on solid phase around a tetrazine so that UV light opens the ring and releases them, turning a cyclic sequence – which tandem MS…
Designs cyclic peptides on solid phase around a tetrazine so that UV light opens the ring and releases them, turning a cyclic sequence – which tandem MS deconvolutes badly, and which most approved peptide drugs are – into a linear one that sequences de novo.
| Kind | algorithm |
| Deep learning | no |
| Acquisition | DDA |
| Family | Chemical derivatization assisted |
Paper describing it
- Facile de Novo Sequencing of Tetrazine‐Cyclized Peptides through UV‐Induced Ring‐Opening and Cleavage from the Solid Phase (2023, ChemBioChem, peer-reviewed)