Hybrid search
5 methods · 2004–2013
Hybrid search: De novo interpretation used to drive a database search: the sequence or the tag read from the spectrum becomes the query, rather than the database enumerating candidates to score.
De novo interpretation used to drive a database search: the sequence or the tag read from the spectrum becomes the query, rather than the database enumerating candidates to score.
The earliest of its 5 methods is VEMS (2004); 4 more have followed.
| Methods | 5 |
| Papers describing them | 5 |
| Authors | 17 |
| Active | 2004-09-01 to 2013-01-21 |
| Kinds | adjacent (5) |
| Acquisition | DDA (5) |
Methods (5)
Oldest first, by the paper that describes each one.
- VEMS (2004): Virtual Expert Mass Spectrometrist: a package for automated and manual de novo MS/MS sequencing combined with database search and an extended search for modified and miscleaved peptides.
- DeNovoID (2005): Web-based tool for identifying peptides from sequence and mass tags deduced from de novo peptide sequencing.
- Lookup Peaks (2007): Hybrid de novo sequencing and database-search method for protein identification by tandem MS.
- De novo cross-check of borderline database hits (2008): Displays rapid de novo interpretations next to each borderline database search hit so ambiguous matches can be checked by eye.
- NovoDB (2013): Protein identification method integrating de novo sequencing with database searching.
Papers describing them (5)
- Database‐independent, database‐dependent, and extended interpretation of peptide mass spectra in VEMS V2.0 (2004, PROTEOMICS, peer-reviewed)
- DeNovoID: a web-based tool for identifying peptides from sequence and mass tags deduced from de novo peptide sequencing by mass spectroscopy (2005, Nucleic Acids Research, peer-reviewed)
- Lookup Peaks: A Hybrid of de Novo Sequencing and Database Search for Protein Identification by Tandem Mass Spectrometry (2007, Analytical Chemistry, peer-reviewed)
- Simplified validation of borderline hits of database searches (2008, PROTEOMICS, peer-reviewed)
- Mass spectrometry-based protein identification by integrating de novo sequencing with database searching (2013, BMC Bioinformatics, peer-reviewed)