Serial derivatization of peptides for de novo sequencing using tandem mass spectrometry

US7371514B2 · Agilent Technologies · priority 2004

Patent US7371514B2 (Agilent Technologies, Expired - Fee Related): Serial derivatization by chemical reactions of analytes for mass spectrometry is disclosed. The derivatizations enhance the use of MS techniques for analyzing protein samples…
Patent US7371514B2 ↗
Status Expired - Fee Related
Priority date 2004-07-16
Filed 2004-07-16
Published (granted) 2008-05-13
Assignee Agilent Technologies (printed Agilent Technologies Inc)
Also published as CN1749269A, CN1766636A, EP1617223A2, EP1617223A3, US20060014210A1

Abstract

Serial derivatization by chemical reactions of analytes for mass spectrometry is disclosed. The derivatizations enhance the use of MS techniques for analyzing protein samples, particularly when the sequence of a polypeptide is determined by tandem MS/MS. Accurate mass analysis techniques are described for use in sequencing polypeptides, together with the use of sequencing data in protein analysis.

Why it is here

Agilent: serial derivatisation (imidazole on lysine, alkylated acidic side chains) for de novo sequencing by tandem MS.

Inventors (3)

Barry E. Boyes, Gordon R. Nicol, Hongbin Liu

An inventor links to an author page only where the same person is evident, never on a name alone.

Catalogued papers it cites (1)

Matched from the patent’s 33 literature citations by the rules the paper citation graph uses.

Cited by catalogued patents (2)

  • CN104034791A CID and ETD mass spectrogram fusion based polypeptide de novo sequencing method
  • CN103852513B A kind of peptide section de novo sequencing method and system based on HCD and ETD mass spectrogram

Cited by (9 patent families, 8 organisations)

Every family, of any applicant, that cites this one, as Google Patents lists them; an assignee is given its English name.

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