Evolutionary Algorithms for Improving De Novo Peptide Sequencing

thesis · 2020

thesis · 2020. Samaneh Azari
Date 2020-01-01
Type thesis
Publisher PhD thesis
Contribution post-processor
DOI 10.26686/wgtn.17145581.v1
Citations (OpenAlex) 1

Authors

  1. Samaneh Azari · Victoria University of Wellington

Methods and tools

  • GA-Novo: Genetic-algorithm approach for de novo peptide sequencing from tandem mass spectra.
  • GP-based scoring function for de novo PSM re-ranking: Genetic-programming-derived scoring function for re-ranking peptide-spectrum matches emitted by de novo sequencing tools. Improves top-k accuracy over the default scorer.

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