Framework for de novo sequencing of peptide mixtures via network analysis and two-dimensional tandem mass spectrometry
peer-reviewed · Chemical Science · 2025
peer-reviewed · Chemical Science · 2025. MyPhuong T. Le et al. A 2D tandem mass spectrum of a peptide mixture is organized into a graphical structure. A graph partitioning…
| Date | 2025-09-04 |
| Type | peer-reviewed |
| Venue | Chemical Science |
| Publisher | Royal Society of Chemistry (RSC) |
| Contribution | algorithm |
| DOI | 10.1039/d5sc03762j |
| Citations (OpenAlex) | 2 |
| Venue 2-year citedness | 7.71 |
Abstract
A 2D tandem mass spectrum of a peptide mixture is organized into a graphical structure. A graph partitioning algorithm extracts the fragmentation trees of individual peptides, and a de novo sequencing algorithm identifies the peptide sequences.
Methods and tools
- 2D-MS network peptide mixtures: Framework for de novo sequencing of peptide mixtures via network analysis and two-dimensional tandem MS.
Cites (7)
- Sequence-to-sequence translation from mass spectra to peptides with a transformer model (2024) crossref
- PowerNovo: de novo peptide sequencing via tandem mass spectrometry using an ensemble of transformer and BERT models (2024) crossref
- Mitigating the missing-fragmentation problem in de novo peptide sequencing with a two-stage graph-based deep learning model (2023) crossref
- Algorithms for de-novo sequencing of peptides by tandem mass spectrometry: A review (2023) crossref
- Deep learning enables de novo peptide sequencing from data-independent-acquisition mass spectrometry (2018) crossref
- Lessons in de novo peptide sequencing by tandem mass spectrometry (2015) crossref
- De Novo Peptide Sequencing and Identification with Precision Mass Spectrometry (2007) crossref