Prime-DiffNovo: Accurate Peptide De Novo Sequencing via Non-autoregressive Generation and Diffusion Refinement
peer-reviewed · Lecture Notes in Computer Science (ISBRA 2026) · 2026
peer-reviewed · Lecture Notes in Computer Science (ISBRA 2026) · 2026. Xuan Yu et al.
| Date | 2026-07-15 |
| Type | peer-reviewed |
| Venue | Lecture Notes in Computer Science (ISBRA 2026) |
| Publisher | Springer Nature Singapore |
| Contribution | algorithm |
| DOI | 10.1007/978-981-92-3719-7_16 |
| Citations (OpenAlex) | 0 |
Methods and tools
- Prime-DiffNovo: Non-autoregressive Transformer de novo peptide sequencer with a diffusion-based refinement step at inference time: the NAR pass drafts a full sequence in parallel, and the diffusion loop iteratively corrects residue predictions to sharpen accuracy.
Data used
- Nine-species benchmark (original (DeepNovo, 2017)) · MSV000081382, PXD003868 (provenance), PXD004325 (provenance), PXD004424 (provenance), PXD004467 (provenance), PXD004536 (provenance), PXD004565 (provenance), PXD004947 (provenance), PXD004948 (provenance), PXD005025 (provenance)
- Nine-species benchmark (revised (main)) · 10.5281/zenodo.12926326, Noble-Lab/multi-species-benchmark, MSV000090982, 10.5281/zenodo.13685813
Cites (13)
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- π-PrimeNovo: an accurate and efficient non-autoregressive deep learning model for de novo peptide sequencing (2025) crossref
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- Algorithms for the de novo sequencing of peptides from tandem mass spectra (2011) crossref
- Performance Evaluation of Existing De Novo Sequencing Algorithms (2006) crossref
- PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry (2003) crossref
- Sequence database searches via de novo peptide sequencing by tandem mass spectrometry (1997) crossref