Prime-DiffNovo: Accurate Peptide De Novo Sequencing via Non-autoregressive Generation and Diffusion Refinement

peer-reviewed · Lecture Notes in Computer Science (ISBRA 2026) · 2026

peer-reviewed · Lecture Notes in Computer Science (ISBRA 2026) · 2026. Xuan Yu et al.
Date 2026-07-15
Type peer-reviewed
Venue Lecture Notes in Computer Science (ISBRA 2026)
Publisher Springer
Contribution algorithm
DOI 10.1007/978-981-92-3719-7_16
Citations (OpenAlex) 0

Authors

  1. Xuan Yu · City University of Hong Kong
  2. Kunyi Li · City University of Hong Kong
  3. Lusheng Wang · City University of Hong Kong

Methods and tools

  • Prime-DiffNovo: Non-autoregressive Transformer de novo peptide sequencer with a diffusion-based refinement step at inference time: the NAR pass drafts a full sequence in parallel, and the diffusion loop iteratively corrects residue predictions to sharpen accuracy.

Cites (13)

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