Toxin identification (biodefense)
1 workflow · 2025
Toxin identification (biodefense): Recognising protein toxins in an unknown sample, where a database search presumes what you are looking for. 1 catalogued workflow and 1 paper.
Recognising protein toxins in an unknown sample, where a database search presumes what you are looking for.
| Workflows | 1 |
| Papers | 1 |
| Authors | 7 |
| Active | 2025-11-18 to 2025-11-18 |
Workflow (1)
- HDPS (2025): Heuristic two-round sequence assembly strategy combining multi-enzyme and microwave-assisted acid hydrolysis, pNovo de novo peptide sequencing, and pFind homology database search with k-mer graph assembly and majority-vote error correction; achieved 100% sequence coverage and >98% amino-acid accuracy on full-length Ricin toxin A and B chains without a reference sequence, outperforming ALPS.
Paper (1)
- Identification of Unknown Biological Toxin Proteins Using Mass Spectrometry: A Case Study on De Novo Sequencing of Ricin (2025, Toxins, peer-reviewed)
Sequencing tools these papers used
Where the work happened
China