Bis-cysteine macrocycle chemical linearization
adjacent · Chemical derivatization assisted
Bis-cysteine macrocycle chemical linearization: adjacent · Chemical derivatization assisted. Cleaves synthetic bis-Cys macrocyclic peptides at a defined backbone position by Edman chemistry so that mixtures from macrocycle libraries can be sequenced…
Cleaves synthetic bis-Cys macrocyclic peptides at a defined backbone position by Edman chemistry so that mixtures from macrocycle libraries can be sequenced de novo by nLC-MS/MS.
| Kind | adjacent |
| Deep learning | no |
| Acquisition | DDA |
| Family | Chemical derivatization assisted |
Paper describing it
- De Novo Sequencing of Synthetic Bis -cysteine Peptide Macrocycles Enabled by “Chemical Linearization” of Compound Mixtures (2023, Analytical Chemistry, peer-reviewed)