Cathepsin middle-down antibody digestion

adjacent · Protease strategy

Cathepsin middle-down antibody digestion: adjacent · Protease strategy. Shows Cathepsins D and L cleave IgGs right after CDR3, producing sequencing-sized fragments for middle-down de novo antibody sequencing.

Shows Cathepsins D and L cleave IgGs right after CDR3, producing sequencing-sized fragments for middle-down de novo antibody sequencing.

Kind	adjacent
Family	Protease strategy

Paper describing it

• The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle‐down characterization of antibodies (2021, The FEBS Journal, peer-reviewed)

Authors (9)

Tomislav Čaval, Elizabeth Sara Hecht, Wilfred H. Tang, Maelia Uy‐Gomez, Andrew Nichols, Yong J. Kil, Wendy Sandoval, Marshall Bern, Albert J. R. Heck

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