Albert J. R. Heck

13 papers in the catalog · Netherlands

Albert J. R. Heck: 13 papers in the catalog · Netherlands · Center for Biomedical Genetics, Netherlands Proteomics Centre · Works on CDR3 sequence-ladder IgG de novo sequencing, COVID-19 IgG1/IgA1 repertoire profiling, Cathepsin middle-down antibody…

Affiliations

Center for Biomedical Genetics
Netherlands Proteomics Centre
Utrecht University · Biomolecular Mass Spectrometry and Proteomics Group, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research
Utrecht University · Department of Pharmaceutical Sciences

Elsewhere

ORCID 0000-0002-2405-4404 · OpenAlex

Papers

Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry (2026, Cell Systems)
Into the Dark Serum Proteome: Personalized Features of IgG1 and IgA1 Repertoires in Severe COVID-19 Patients (2024, Molecular & Cellular Proteomics)
Direct Mass Spectrometry-Based Detection and Antibody Sequencing of Monoclonal Gammopathy of Undetermined Significance from Patient Serum: A Case Study (2023, Journal of Proteome Research)
A perspective toward mass spectrometry-based de novo sequencing of endogenous antibodies (2022, mAbs)
No patient is the same; lessons learned from antibody repertoire profiling in hospitalized severe COVID-19 patients (2022, medRxiv)
Human plasma IgG1 repertoires are simple, unique, and dynamic (2021, Cell Systems)
The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle‐down characterization of antibodies (2021, The FEBS Journal)
Selectivity over coverage in de novo sequencing of IgGs (2020, Chemical Science)
De novo sequencing of two novel peptides homologous to calcitonin-like peptides, from skin secretion of the Chinese Frog, Odorrana schmackeri (2015, EuPA Open Proteomics)
Database independent proteomics analysis of the ostrich and human proteome (2012, Proceedings of the National Academy of Sciences)
Dimethyl isotope labeling assisted de novo peptide sequencing (2010, Journal of the American Society for Mass Spectrometry)
LysNDeNovo: An algorithm enabling de novo sequencing of Lys‐N generated peptides fragmented by electron transfer dissociation (2010, PROTEOMICS)
Straightforward and de Novo Peptide Sequencing by MALDI-MS/MS Using a Lys-N Metalloendopeptidase (2009, Molecular & Cellular Proteomics)

Methods and tools

CDR3 sequence-ladder IgG de novo sequencing, COVID-19 IgG1/IgA1 repertoire profiling, Cathepsin middle-down antibody digestion, Dimethyl isotope labeling de novo sequencing, Endogenous antibody de novo sequencing (perspective), HTA-protease de novo antibody sequencing, Human plasma IgG1 repertoire profiling, Lys-N ETD database-independent proteomics, Lys-N MALDI-MS/MS de novo sequencing, LysNDeNovo, MGUS M-protein sequencing from serum, Odorrana schmackeri calcitonin-like peptides

Co-authors (74)

Ranked by Newman fractional collaboration strength, so a pair on a two-author paper counts for more than a pair on a 50-author consortium paper.

Shabaz Mohammed strength 0.94, 5 shared
Sem Tamara strength 0.83, 6 shared
A. F. Maarten Altelaar strength 0.64, 3 shared
Albert Bondt strength 0.49, 5 shared
Maurits A. den Boer strength 0.49, 5 shared
Max Hoek strength 0.49, 4 shared
Bas van Breukelen strength 0.37, 2 shared
Joost Snijder strength 0.35, 5 shared
Nadia Taouatas strength 0.34, 2 shared
Marco L. Hennrich strength 0.33, 1 shared
Sebastiaan C. de Graaf strength 0.33, 1 shared
Jean-François Greisch strength 0.33, 2 shared
Douwe Schulte strength 0.31, 4 shared
Weiwei Peng strength 0.24, 4 shared
Alexandros Georgiou strength 0.20, 1 shared
Madalina M. Drugan strength 0.20, 1 shared
Berend Snel strength 0.17, 1 shared
Danny Navarro strength 0.17, 1 shared
Jos Boekhorst strength 0.17, 1 shared
Bastiaan de Graaf strength 0.16, 3 shared
Danique M.H. van Rijswijck strength 0.16, 3 shared
Darryl J. Pappin strength 0.14, 1 shared
Joost W. Gouw strength 0.14, 1 shared
Paul J. Boersema strength 0.14, 1 shared
Philip L. Ross strength 0.14, 1 shared
Andrew Nichols strength 0.12, 1 shared
Elizabeth Sara Hecht strength 0.12, 1 shared
Maelia Uy‐Gomez strength 0.12, 1 shared
Marshall Bern strength 0.12, 1 shared
Tomislav Čaval strength 0.12, 1 shared
Wendy Sandoval strength 0.12, 1 shared
Wilfred H. Tang strength 0.12, 1 shared
Yong J. Kil strength 0.12, 1 shared
Allison Michele Narlock-Brand strength 0.11, 1 shared
Laura Pérez Pañeda strength 0.11, 1 shared
Patrick A. Pribil strength 0.11, 1 shared
Sibylle Heidelberger strength 0.11, 1 shared
Steven M. Yannone strength 0.11, 1 shared
Tatiana M. Shamorkina strength 0.11, 1 shared
Tereza Kadavá strength 0.11, 1 shared

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