Champs

adjacent · Homology search

Champs: adjacent · Homology search. Sequences a complete novel protein by de novo sequencing its peptides and then assembling them against a HOMOLOGOUS database rather than an exact one, reaching near-full…

Sequences a complete novel protein by de novo sequencing its peptides and then assembling them against a HOMOLOGOUS database rather than an exact one, reaching near-full coverage and accuracy where neither approach alone would.

Kind	adjacent
Deep learning	no
Acquisition	DDA
Family	Homology search

Papers describing it (2)

• Automated protein (re)sequencing with MS/MS and a homologous database yields almost full coverage and accuracy (2009, Bioinformatics, peer-reviewed)
• Integrating de novo Sequencing and Database Search for Monoclonal Antibody Sequencing (2013, Europe PMC (PubMed Central), abstract)

Authors (6)

Xiaowen Liu, Yonghua Han, Denis Yuen, Bin Ma, Xin Lei, Baozhen Shan

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• The architectures
• Models and the authors behind them

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