Integrating de novo Sequencing and Database Search for Monoclonal Antibody Sequencing

abstract · Europe PMC (PubMed Central) · 2013

abstract · Europe PMC (PubMed Central) · 2013. Xin Lei et al.
Date 2013-05-01
Type abstract
Venue Europe PMC (PubMed Central)
Contribution adjacent
Link https://www.ncbi.nlm.nih.gov/pmc/articles/3635332
Citations (OpenAlex) 1

Authors

  1. Xin Lei
  2. Baozhen Shan · Bioinformatics Solutions (Canada), Bioinformatics Solutions Inc., Western University

Methods and tools

  • Champs: Sequences a complete novel protein by de novo sequencing its peptides and then assembling them against a HOMOLOGOUS database rather than an exact one, reaching near-full coverage and accuracy where neither approach alone would.

Methods it uses

  • PEAKS: Commercial DP-based de novo

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