Composition-based sequencing
algorithm · Constrained search
Composition-based sequencing: algorithm · Constrained search. Two-step database-free strategy enabled by FT-ICR mass accuracy: determine the peptide’s amino acid COMPOSITION first, then score only the permutations that composition…
Two-step database-free strategy enabled by FT-ICR mass accuracy: determine the peptide’s amino acid COMPOSITION first, then score only the permutations that composition allows, which is a far smaller search space than conventional de novo sequencing explores.
| Kind | algorithm |
| Deep learning | no |
| Acquisition | DDA |
| Family | Constrained search |
Papers describing it (3)
- De novo sequencing, peptide composition analysis, and composition-based sequencing: A new strategy employing accurate mass determination by Fourier transform ion cyclotron resonance mass spectrometry (2004, Journal of the American Society for Mass Spectrometry, peer-reviewed)
- Direct Protein Identification from Nonspecific Peptide Pools by High‐Accuracy MS Data Filtering (2006, Angewandte Chemie International Edition, peer-reviewed)
- Accurate Mass as a Bioinformatic Parameter in Data-to-Knowledge Conversion: Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Peptide De Novo Sequencing (2007, European Journal of Mass Spectrometry, peer-reviewed)
Papers using it (2)
Applications and evaluations that ran this method. They are not counted among its authors below.
- Isolation and sequence analysis of peptides from the skin secretion of the Middle East tree frog Hyla savignyi (2010, Analytical and Bioanalytical Chemistry, peer-reviewed)
- Characterization of a peptide family from the skin secretion of the Middle East Tree Frog Hyla savignyi by composition‐based de novo sequencing (2010, Rapid Communications in Mass Spectrometry, peer-reviewed)