Composition-based sequencing
algorithm · Constrained search
Composition-based sequencing: algorithm · Constrained search. Two-step database-free strategy enabled by FT-ICR mass accuracy: determine the peptide’s amino acid COMPOSITION first, then score only the permutations that composition…
Two-step database-free strategy enabled by FT-ICR mass accuracy: determine the peptide’s amino acid COMPOSITION first, then score only the permutations that composition allows, which is a far smaller search space than conventional de novo sequencing explores.
| Kind | algorithm |
| Family | Constrained search |
| Deep learning | no |
| Acquisition | DDA |
Papers
- De novo sequencing, peptide composition analysis, and composition-based sequencing: A new strategy employing accurate mass determination by Fourier transform ion cyclotron resonance mass spectrometry (2004, Journal of the American Society for Mass Spectrometry, peer-reviewed)