Continuous digestion MS3 Leu/Ile discrimination

adjacent · Fragment ion analysis

Continuous digestion MS3 Leu/Ile discrimination: adjacent · Fragment ion analysis. Combines continuous enzymatic digestion, to expose Leu/Ile at peptide N-termini, with a combined verification score over multiple MS3 spectra, resolving 67 of 68…

Combines continuous enzymatic digestion, to expose Leu/Ile at peptide N-termini, with a combined verification score over multiple MS3 spectra, resolving 67 of 68 Leu/Ile sites in trastuzumab.

Kind	adjacent
Deep learning	no
Acquisition	DDA
Family	Fragment ion analysis

Paper describing it

• Accurate discrimination of leucine and isoleucine residues by combining continuous digestion with multiple MS3 spectra integration in protein sequence (2022, Talanta, peer-reviewed)

Authors (7)

Weijie Zhang, Chao Yang, Jianhui Liu, Zhen Liang, Yichu Shan, Lihua Zhang, Yukui Zhang

Seen in the charts

• The architectures
• Models and the authors behind them

Back to the full map