COVID-19 IgG1/IgA1 repertoire profiling

downstream-application

COVID-19 IgG1/IgA1 repertoire profiling: downstream-application. Longitudinal intact-mass profiling of IgG1 and IgA1 clonal repertoires in severe COVID-19 patients, with dominant clones sequenced de novo by combined top-down…

Longitudinal intact-mass profiling of IgG1 and IgA1 clonal repertoires in severe COVID-19 patients, with dominant clones sequenced de novo by combined top-down, middle-down and bottom-up proteomics.

Kind	downstream-application
Deep learning	no
Acquisition	DDA
Application area	Antibodyomics

Papers describing it (2)

• No patient is the same; lessons learned from antibody repertoire profiling in hospitalized severe COVID-19 patients (2022, medRxiv, preprint)
• Into the Dark Serum Proteome: Personalized Features of IgG1 and IgA1 Repertoires in Severe COVID-19 Patients (2024, Molecular & Cellular Proteomics, peer-reviewed)

Authors (26)

Albert Bondt, Max Hoek, Kelly Dingess, Sem Tamara, Bastiaan de Graaf, Weiwei Peng, Maurits A. den Boer, Mirjam Damen, Ceri Zwart, Arjan Barendregt, Danique M.H. van Rijswijck, Marloes Grobben, Khadija Tejjani, Jacqueline van Rijswijk, Franziska Völlmy, Joost Snijder, Francesca Fortini, Alberto Papi, Carlo Alberto Volta, Gianluca Campo, Marco Contoli, Marit J. van Gils, Savino Spadaro, Paola Rizzo, Albert J. R. Heck, Douwe Schulte

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