Isotopic differentiation protocol (IDP)
adjacent · Chemical labeling assisted
Isotopic differentiation protocol (IDP): adjacent · Chemical labeling assisted. Forms light and deuterated methyl esters at the C-terminus or acetamides at the N-terminus so that mass shifts between isotopologues pick out C- and N-terminal ion…
Forms light and deuterated methyl esters at the C-terminus or acetamides at the N-terminus so that mass shifts between isotopologues pick out C- and N-terminal ion series for de novo sequencing.
| Kind | adjacent |
| Deep learning | no |
| Acquisition | DDA |
| Family | Chemical labeling assisted |
Paper describing it
- Isotopic Differentiation Protocol, a Selective Extraction of C- and N-Terminal Ions in ESI-Ms/Ms De Novo Peptide Sequencing (2015, Natural Products Chemistry & Research, peer-reviewed)