MGUS M-protein sequencing from serum

downstream-application

MGUS M-protein sequencing from serum: downstream-application. Detected a monoclonal gammopathy in patient serum and sequenced the full Fab-glycosylated M-protein by multi-protease bottom-up de novo sequencing with template…

Detected a monoclonal gammopathy in patient serum and sequenced the full Fab-glycosylated M-protein by multi-protease bottom-up de novo sequencing with template assembly, validated by top-down MS.

Kind	downstream-application
Deep learning	no
Acquisition	DDA
Application area	Antibodyomics

Paper describing it

• Direct Mass Spectrometry-Based Detection and Antibody Sequencing of Monoclonal Gammopathy of Undetermined Significance from Patient Serum: A Case Study (2023, Journal of Proteome Research, peer-reviewed)

Authors (13)

Weiwei Peng, Maurits A. den Boer, Sem Tamara, Nadia J. Mokiem, Sjors P. A. van der Lans, Albert Bondt, Douwe Schulte, Pieter-Jan Haas, Monique C. Minnema, Suzan H. M. Rooijakkers, Arjan D. van Zuilen, Albert J. R. Heck, Joost Snijder

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