Parallel synthesis + de novo peptide screening
downstream-application
Parallel synthesis + de novo peptide screening: downstream-application. Joint technique pairing de novo sequencing of a simulated-digestion hydrolysate with parallel peptide synthesis, so each predicted sequence is synthesised, screened for…
Joint technique pairing de novo sequencing of a simulated-digestion hydrolysate with parallel peptide synthesis, so each predicted sequence is synthesised, screened for activity and checked against the standard’s retention time and MS/MS spectrum. Applied to sea cucumber and seahorse.
| Kind | downstream-application |
| Deep learning | no |
| Acquisition | DDA |
| Application area | Bioactive peptides |
Papers describing it (3)
- Efficient Screening of Synergistic Antioxidant and AChE Inhibitory Peptides From Sea Cucumber (Stichopus japonicus) Using a Novel Approach Combining De Novo Sequencing and Parallel Peptide Synthesis (2025, Peptide Science, peer-reviewed)
- Efficient Screening of α-Glucosidase Inhibitory Peptides From Seahorse Through the Innovative Joint Technique: De Novo Sequencing and Parallel SPOT Synthesis (2025, Journal of Peptide Science, peer-reviewed)
- Joint technique “parallel peptide synthesis & de novo sequencing” development for the structure verification and high-throughput activity screening of biological peptides from sea cucumber (Stichopus japonicus) intestinal hydrolysate (2025, Food Research International, peer-reviewed)