pNovoM

algorithm · Spectra pair

pNovoM: algorithm · Spectra pair. De novo sequencing from mirror spectrum pairs: digesting the same sample with Ac-LysargiNase and with trypsin yields two spectra whose b and y ion series complement each…

De novo sequencing from mirror spectrum pairs: digesting the same sample with Ac-LysargiNase and with trypsin yields two spectra whose b and y ion series complement each other, which pins down the sequence far more confidently than either alone.

Kind	algorithm
Family	Spectra pair
Deep learning	no
Acquisition	DDA

Papers

• Precision De Novo Peptide Sequencing Using Mirror Proteases of Ac-LysargiNase and Trypsin for Large-scale Proteomics (2019, Molecular & Cellular Proteomics, peer-reviewed)

Authors (15)

Hao Yang, Yanchang Li, Ming-Zhi Zhao, Fei-Lin Wu, Xi Wang, Wei-Di Xiao, Yi-Hao Wang, Jun-Ling Zhang, Fu-Qiang Wang, Feng Xu, Wen-Feng Zeng, Christopher M. Overall, Si-Min He, Hao Chi, Ping Xu

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