PXleS
adjacent · Fragment ion analysis
PXleS: adjacent · Fragment ion analysis. Predictor for Xle Sites: combines leucine aminopeptidase and chymotrypsin selectivity experiments with germline frequencies in a logistic regression that calls Leu or…
Predictor for Xle Sites: combines leucine aminopeptidase and chymotrypsin selectivity experiments with germline frequencies in a logistic regression that calls Leu or Ile at ambiguous sites in de novo sequenced mAbs, at 96% accuracy.
| Kind | adjacent |
| Deep learning | no |
| Acquisition | DDA |
| Family | Fragment ion analysis |
Paper describing it
- A Quantitative Tool to Distinguish Isobaric Leucine and Isoleucine Residues for Mass Spectrometry-Based De Novo Monoclonal Antibody Sequencing (2014, Journal of the American Society for Mass Spectrometry, peer-reviewed)