uMetaP / novoMP

downstream-application

uMetaP / novoMP: downstream-application. Ultra-sensitive gut metaproteomics workflow with an FDR-validated de novo strategy (novoMP) that expands the dark metaproteome and maps host-microbiome interactions in…

Ultra-sensitive gut metaproteomics workflow with an FDR-validated de novo strategy (novoMP) that expands the dark metaproteome and maps host-microbiome interactions in intestinal injury.

Kind	downstream-application
Acquisition	DDA
Application area	Metaproteomics

Papers describing it (2)

• Ultra-sensitivity metaproteomics redefines the gut “dark metaproteome”, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases (2024, bioRxiv, preprint)
• Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases (2025, Nature Communications, peer-reviewed)

Authors (15)

Feng Xian, Malena Brenek, Christoph Krisp, Doriane Aguanno, Elisabeth Urbauer, Tharan Srikumar, Ranjith Kumar Ravi Kumar, Qixin Liu, Allison M. Barry, Bin Ma, Jonathan Krieger, Dirk Haller, Manuela Schmidt, David Gómez-Varela, Jonathan R. Krieger

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