PGPointNovo: an efficient neural network-based tool for parallel de novo peptide sequencing
peer-reviewed · Bioinformatics Advances · 2023
| Date | 2023-04-25 |
| Type | peer-reviewed |
| Venue | Bioinformatics Advances |
| Publisher | Bioinformatics Advances |
| Contribution | algorithm |
| DOI | 10.1093/bioadv/vbad057 |
| Citations (OpenAlex) | 9 |
| Venue 2-year citedness | 2.22 |
Abstract
Summary De novo peptide sequencing for tandem mass spectrometry data is not only a key technology for novel peptide identification, but also a precedent task for many downstream tasks, such as vaccine and antibody studies. In recent years, neural network models for de novo peptide sequencing have manifested a remarkable ability to accommodate various data sources and outperformed conventional peptide identification tools. However, the excellent model is computationally expensive, taking up to 1 week to process about 400 000 spectrums. This article presents PGPointNovo, a novel neural network-based tool for parallel de novo peptide sequencing. PGPointNovo uses data parallelization technology to accelerate training and inference and optimizes the training obstacles caused by large batch sizes. The results of extensive experiments conducted on multiple datasets of different sizes demonstrate that compared with PointNovo the excellent neural network-based de novo peptide sequencing tool, PGPointNovo, accelerates de novo peptide sequencing by up to 7.35× without precision or recall compromises. Availability and implementation The source code and the parameter settings are available at https://github.com/shallFun4Learning/PGPointNovo. Supplementary information Supplementary data are available at Bioinformatics Advances online.
Methods and tools
- PGPointNovo: Parallel GPU-based PointNovo
Cites (4)
- Computationally instrument-resolution-independent de novo peptide sequencing for high-resolution devices (2021) both
- De novo sequencing of proteins by mass spectrometry (2020) both
- De novo peptide sequencing by deep learning (2017) both
- MRUniNovo: an efficient tool for de novo peptide sequencing utilizing the Hadoop distributed computing framework (2017) both
Cited by (5)
- AbNovoBench: a resource and benchmarking platform for monoclonal antibody de novo sequencing (2026) crossref
- MassNet: billion-scale AI-friendly mass spectral corpus enables robust de novo peptide sequencing (2025) crossref
- De Novo Peptide Sequencing for Data-independent Acquisition (DIA) Using Deep Learning (2025) crossref
- Deep Learning Methods for De Novo Peptide Sequencing (2024) crossref
- A learned score function improves the power of mass spectrometry database search (2024) crossref