borgonovo

post-processor · Sequence assembly

borgonovo: post-processor · Sequence assembly. Reference-free protein sequencer: multi-protease digestion tiles a protein with overlapping peptides, and the redundant de novo reads are assembled into a per-residue…

Reference-free protein sequencer: multi-protease digestion tiles a protein with overlapping peptides, and the redundant de novo reads are assembled into a per-residue consensus by substitution-tolerant alignment and per-column voting. Re-decoding each spectrum under a prior from its consensus position raises amino-acid accuracy. Wraps Casanovo by default but is backend-agnostic.

Kind	post-processor
Family	Sequence assembly
Deep learning	no
Acquisition	DDA

Code

• https://github.com/statisticalbiotechnology/borgonovo

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Papers

• Reference-free protein sequencing by consensus assembly of redundant de novo peptide reads (2026, bioRxiv, preprint)

Authors (6)

Alfred Nilsson, Emil Sporre, Douwe Schulte, Joost Snijder, Fredrik Edfors, Lukas Käll

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